Our “off the shelf” stem cells deliver a viral payload that first kills cancer cells locally, and then supercharges the immune system to fight metastatic disease.
We are developing a new generation of targeted immunotherapies that attack solid tumors, and then teach the immune system to hunt down cancer cells elsewhere in the body.
The approach to
finding a cure is in
our name:
Tumors evade the immune system by becoming immunologically “cold”, appearing to be normal cells. From the Latin word for hot (calidus), Calidi’s platforms help the immune system recognize cancer cells, making them “hot” tumors that immune cells can then attack and destroy.
Discover the future of biotherapeutics with Calidi. Pioneering innovative solutions for solid tumors.
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Latest News
Calidi Biotherapeutics Announces Shareholder Letter from CEO
Calidi Biotherapeutics Announces Shareholder Letter from CEO SAN DIEGO, June 27, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company pioneering the development of…
Calidi Biotherapeutics Presents Systemic Oncolytic Platform with CD55-Enhanced Expression and IL-15 Superagonist Payload at ASCO Annual Meeting
Calidi Biotherapeutics Presents Systemic Oncolytic platform with CD55-Enhanced Expression and IL-15 Superagonist Payload at ASCO Annual Meeting San Diego, CA – June 2, 2025 — Calidi Biotherapeutics Inc. (NYSE American:…
Calidi Biotherapeutics Reports First Quarter 2025 Financial Results and Recent Operational Highlights
Calidi Biotherapeutics Reports First Quarter 2025 Financial Results and Recent Operational Highlights Bolstered management team with hires of Chief Executive Officer and Chief Medical Officer with deep biopharmaceutical experience Announced…
Calidi Biotherapeutics Announces IL15 Superagonist as First Payload to be Delivered by Systemic Antitumor Virotherapy Platform at AACR Annual Meeting
SAN DIEGO, April 28, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced the…
Calidi Biotherapeutics Reports Inducement Grant Under NYSE American LLC Company Guide Section 711
SAN DIEGO, April 25, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced that…
Calidi Biotherapeutics Announces Chief Executive Officer Transition and Appointment of Eric Poma, Ph.D. as CEO and Director
SAN DIEGO, April 23, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced the…
Join Calidi Biotherapeutics’ Exclusive Live Investor Webinar and Q&A Session on April 24
SAN DIEGO, April 22, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, is pleased to…
Calidi Biotherapeutics Announces FDA Clearance of IND Application for CLD-201 in Solid Tumors
SAN DIEGO, April 17, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company pioneering targeted antitumor virotherapies, announced today that the U.S. Food and…
Calidi Biotherapeutics Announces Appointment of Guy Travis Clifton, MD as Chief Medical Officer, Consultant and Advisor
SAN DIEGO, April 10, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, today announced the…
Calidi Biotherapeutics Announces Closing of $3.9 Million Registered Direct Offering and Concurrent Private Placement
SAN DIEGO, March 31, 2025 (GLOBE NEWSWIRE) — Calidi Biotherapeutics, Inc. (NYSE AMERICAN: CLDI) (“Calidi” or the “Company”), a clinical-stage biotechnology company developing a new generation of targeted immunotherapies, today announced…